Monophosphoryl lipid A induces protection against LPS in medullary thick ascending limb through a TLR4-TRIF-PI3K signaling pathway
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منابع مشابه
Ammonium carriers in medullary thick ascending limb.
Absorption of NH(4)(+) by the medullary thick ascending limb (MTAL) is a key event in the renal handling of NH(4)(+), leading to accumulation of NH(4)(+)/NH(3) in the renal medulla, which favors NH(4)(+) secretion in medullary collecting ducts and excretion in urine. The Na(+)-K(+)(NH(4)(+))-2Cl(-) cotransporter (BSC1/NKCC2) ensures approximately 50-65% of MTAL active luminal NH(4)(+) uptake un...
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Cyclooxygenase-2 (Cox-2) is an inducible enzyme responsible for the formation of inflammatory prostanoids such as prostaglandins and thromboxane. Its role in the pathophysiology of inflammatory states like sepsis is increasingly recognized. Recently, we demonstrated that sepsis upregulates the endotoxin receptor Toll-like receptor 4 (TLR4) in rat kidney. Because Cox-2 is one of the downstream p...
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Although aldosterone influences a variety of cellular processes through nongenomic mechanisms, the significance of nongenomic pathways for aldosterone-induced regulation of epithelial function is not understood. Recently, we demonstrated that aldosterone inhibits transepithelial HCO(3)(-) absorption in the medullary thick ascending limb (MTAL) through a nongenomic pathway. This inhibition is me...
متن کاملLumen LPS inhibits HCO 3 - absorption in medullary thick ascending limb through 2 TLR 4 - PI 3 K - Akt - mTOR - dependent inhibition of basolateral Na + / H + exchange 3 4
32 Sepsis and endotoxemia induce defects in renal tubule function but the mechanisms are 33 poorly understood. Recently we demonstrated that lipopolysaccharide (LPS) inhibits HCO3 34 absorption in the medullary thick ascending limb (MTAL) through activation of different Toll-like 35 receptor 4 (TLR4) signaling pathways in the basolateral and apical membranes. Basolateral 36 LPS inhibits HCO3 ab...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Renal Physiology
سال: 2017
ISSN: 1931-857X,1522-1466
DOI: 10.1152/ajprenal.00064.2017